Formulation And Release Characteristics Of Sustained Release Diltiazem Hydrochloride Tablet Pdf

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Formulation and Evaluation of Sustained Release Matrix Tablets of Nifedipine

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Modified-release dosage

Conventional drug delivery system for treating the angina and hypertension are not much effective as the drug do not reach the site of action in appropriate amounts. Thus potent and guarded therapy of this angina and hypertension disorder using specific drug delivery system is a challenging task to the pharmaceutical professionals. Most oftenly used method of regulating the drug release is to include it in a matrix system because of their pliability, hydrophilic polymer matrices are widely used in oral controlled drug delivery to obtain a desirable drug release pattern, methodical, and broad regulatory compliance. Formulation of Nifedipine sustained release matrix tablet was prepared by the polymers blend with to get desirable drug release profile. Evaluation parameters of formulated tablets were hardness, friability, thickness, drug content uniformity weight variation, and the in vitro drug release rate pattern.

Modified-release dosage is a mechanism that in contrast to immediate-release dosage delivers a drug with a delay after its administration delayed-release dosage or for a prolonged period of time extended-release [ER, XR, XL] dosage or to a specific target in the body targeted-release dosage. Sustained-release dosage forms are dosage forms designed to release liberate a drug at a predetermined rate in order to maintain a constant drug concentration for a specific period of time with minimum side effects. This can be achieved through a variety of formulations, including liposomes and drug-polymer conjugates an example being hydrogels. Sustained release's definition is more akin to a "controlled release" rather than "sustained". Extended-release dosage consists of either sustained-release SR or controlled-release CR dosage. SR maintains drug release over a sustained period but not at a constant rate.

Tripathi , Amit Alexander , Ajazuddin. Email s : ajazuddin rungta. DOI: The ability to inhibit the influx of calcium ion present in of cardiac and vascular smooth muscle during membrane depolarization is believed to be its therapeutic effect. It is widely used in the treatment of several types of cardiovascular disorders. For achieving better drug product effectiveness, reliability and safety in the modern pharmaceutical design and intensive research, controlled release and extended release drug delivery has become standards.

WO1990006107A1 - Sustained release diltiazem formulation - Google Patents

The aim of the present study was to develop controlled-release pellets of diltiazem HCl with ethyl cellulose and hydroxylpropyl methylcellulose phthalate as the release rate retarding polymers by fluid bed coating technique. Stability studies were carried out on the optimized formulations for a period of 3 months. The drug release rate decreased as the concentration of ethyl cellulose increased in the pellet formulations. SEM photographs confirmed that the prepared formulations were spherical in nature with a smooth surface.

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