Streptozotocin Induced Diabetic Models In Mice And Rats Pdf

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Experimental Diabetes Mellitus in Different Animal Models

Pamela M. Martin, Penny Roon, Tracy K. Neuronal cell death has been reported in retinas of humans with diabetic retinopathy and in diabetic rat models. Little is known about neuronal cell death in mouse models of diabetic retinopathy. This study was designed to determine whether neurons are lost in diabetic mouse retinas and whether the loss involves an apoptotic process.

Quercetin liposomes ameliorate streptozotocin-induced diabetic nephropathy in diabetic rats

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. A group of healthy rats served as the normal control. The fasting blood glucose FBG , body weights BWs , renal hypertrophy index rHI , serum and urine biochemistry, renal histopathology, oxidative stress and immunohistochemical measurements of AGEs were analyzed to compare the effect of different treatments.

Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Also described are protocols for creating animal models for type 2 diabetes using STZ. View on Wiley. Save to Library. Create Alert.

Improving the Reliability and Utility of Streptozotocin-Induced Rat Diabetic Model

Metrics details. The aim of the present study was to investigate the effects of ginger on various tissues i. The pleasant aroma of ginger comes from the constituents present in its volatile oil, while its non-volatile pungent phytochemicals consist of gingerols, shogaols, and paradols. This research was conducted to determine the effects of 6-shogaol administration on blood glucose and insulin production in type 1 diabetic mice.

Streptozotocin‐Induced Diabetic Models in Mice and Rats

Department of Therapeutics, Chromocell Corporation, U. Regarding the data availability, all data used to support the findings of this study are included within the article. The Streptozotocin- STZ- induced diabetic model is widely used; however, unexplained acute toxicity has given the model an unreliable reputation. To improve the reliability and utility of this model, we characterize the age dependence of STZ toxicity and introduce novel endpoints to assess diabetic complications and reveal possible mechanisms for diabetic development. Their metabolic glucose, lipids, and hormones , inflammatory cytokines , histologic and behavioral endpoints were observed for 1. Analgesic compounds were assessed for efficacy treating neuropathy. Unique noninvasive observational measurements, such as haircoat quality and diarrhea scores, served as useful endpoints for this model.

This is an open access article distributed under the terms of Creative Commons Attribution License. Diabetes mellitus DM is a metabolic disease characterized by abnormal glucose metabolism 1. The disease can cause a number of complications that affect the quality of life of patients 2 , 3.

Introduction

Diabetes is a disease characterized by a relative or absolute lack of insulin, leading to hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes. Type 1 diabetes is due to an autoimmune destruction of the insulin-producing pancreatic beta cells, and type 2 diabetes is caused by insulin resistance coupled by a failure of the beta cell to compensate. Animal models for type 1 diabetes range from animals with spontaneously developing autoimmune diabetes to chemical ablation of the pancreatic beta cells. Type 2 diabetes is modelled in both obese and non-obese animal models with varying degrees of insulin resistance and beta cell failure.

The Streptozotocin- STZ- induced diabetic model is widely used; however, unexplained acute toxicity has given the model an unreliable reputation. To improve the reliability and utility of this model, we characterize the age dependence of STZ toxicity and introduce novel endpoints to assess diabetic complications and reveal possible mechanisms for diabetic development. Their metabolic glucose, lipids, and hormones , inflammatory cytokines , histologic and behavioral endpoints were observed for 1. Analgesic compounds were assessed for efficacy treating neuropathy. Unique noninvasive observational measurements, such as haircoat quality and diarrhea scores, served as useful endpoints for this model. Voltage-gated sodium channel NaV1. Although most patients are type 2 diabetics because hyperglycemia is the principal factor in the etiology and pathogenesis of diabetic complications, both type 1 and type 2 diabetic models are used to study diabetic complications and their potential treatment [ 1 — 3 ].

Javascript is currently disabled in your browser. Several features of this site will not function whilst javascript is disabled. Authors Wu J, Yan L. Received 5 February Published 2 April Volume Pages — Review by Single anonymous peer review. Editor who approved publication: Professor Ming-Hui Zou.

Animal models have historically played a critical role in the exploration and characterization of disease pathophysiology and target identification and in the evaluation of novel therapeutic agents and treatments in vivo. Diabetes mellitus disease, commonly known as diabetes, is a group of metabolic disorders characterized by high blood glucose levels for a prolonged time. To avoid late complications of diabetes and related costs, primary prevention and early treatment are therefore necessary.

Mice were monitored for 30 d for adverse side effects, blood glucose, and insulin requirements.

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